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 หัวเรื่อง:ไม่มีชื่อไทย (ชื่ออังกฤษ : Influence of Training Exercise on Clinical Plasma Chemistry Parameters and Cardiac Markers in Race Horses) ผู้เขียน: นางชูศรี ศรีเพ็ญ, ผู้ช่วยศาสตราจารย์ ,  Anuchit Sitthichaiyakul, Yuwadee Kongpiromchean, นายโฆษิต ศรีเพ็ญ, อาจารย์ สื่อสิ่งพิมพ์:pdf AbstractPhysiological variations of clinical chemistry parameters as a function of exercise reflecting general health and performance are largely unknown in race horses. To assess changes in blood biochemical variables, with special emphasis on cardiac markers, blood samples were drawn from twelve healthy race horses (6 males and 6 females; age range from 2 to 6 years) before and after the exercise training. Biochemical parameters in the renal, liver and lipid profile as well as the muscle enzymes creatine kinase (CK), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) were measured with standard methods using an automated analyzer Hitachi 917 (Roche Diagnostics). Cardiac troponin I (cTnI) plasma concentrations were analyzed with immunometric luminescence technology utilizing an automated immunoassay analyzer Vitros ECi (Ortho-Clinical Dianostic). With the exception of triglycerides, all other biochemical variables showed increased levels after the exercise, with values for alanine aminotransferase (ALT), albumin and total protein reaching statistical significance. The activities of CK and LDH, but not of AST, also displayed a significant increase after the training. Comparing with pre-exercise mean value of 0.015 ng/ml, a more than 10 fold increase in cTnI concentration (0.177 ng/ml) was observed, with a maximum value as high as 0.498 ng/ml. The majority of animals (58%) showed levels exceeding lower cut-off concentration of cTnI at 0.12 ng/ml indicative of a small myocyte injury. In conclusion, small changes in levels of the routine blood chemistry parameters due to training exercise are common in race horses. There was biochemical evidence of minor myocardial cell damage as assessed by cardiac troponin I plasma concentrations. |
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หัวเรื่อง:ไม่มีชื่อไทย (ชื่ออังกฤษ : Age-Related Differences in Levels of Blood Chemistry Parameters and Cardiac Marker Proteins in Commercial Broilers) ผู้เขียน:นางชูศรี ศรีเพ็ญ, ผู้ช่วยศาสตราจารย์, ดร.อาภัสสรา ชูเทศะ, รองศาสตราจารย์, ดร.ทวีศักดิ์ ส่งเสริม, ศาสตราจารย์ , นายโฆษิต ศรีเพ็ญ, อาจารย์ สื่อสิ่งพิมพ์:pdf AbstractThe effect of age on levels of blood biochemical parameters in broiler chickens is largely unknown. The purpose of the present study was to investigate physiological alterations of blood chemistry variables in renal, liver, lipid and cardiac profile in commercial broilers at the age of 2(n=20) and 7 weeks (n=40). The results showed that compared with broiler chicks at the age of 7 weeks, those at the age of 2 weeks had significantly higher levels of blood urea nitrogen, creatinine, uric acid, triglycerides and the enzymes alanine aminotransferase and alkaline phosphatase. Older chicks, on the other hand, displayed significantly higher levels of total protein, albumin, total cholesterol and the enzyme gammaglutamyl transferase. Although a significantly higher activity of cardiac enzyme aspartate aminotransferase and a significantly lower activity of lactate dehydrogenase were observed in older chickens, younger broilers exhibited a significantly higher concentration of the cardiac-specific marker troponin T. There was no significant age-related difference either in the levels of cardiac enzymes creatine kinase, creatine kinase MB or in glucose level. Cardiac troponin T concentration correlated significantly with that of CK-MB in both groups of animals studied. These results underline the importance of age as a significant contributor of variation in levels of several blood chemistry parameters and cardiac marker proteins, especially cardiac troponin T in broiler chicks. |
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